Blood flow meets mitophagy
Authors
- E.B. Akmeriç
- H. Gerhardt
Journal
- Journal of Cell Biology
Citation
- J Cell Biol 221 (7): e202206033
Abstract
Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2's varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2's transcriptional dynamics.